In Once Human, the gear and weapons you choose are the backbone of your combat prowess. Whether you're battling corrupted beasts in PvE zones or launching raids on player settlements in PvP, having a well-crafted build can mean the difference between emerging victorious and having to start from scratch.
This comprehensive guide delves into four of the most potent builds in the latest version of Once Human. We'll provide detailed insights into weapons, gear modifications, synergy effects, and playstyle strategies. Whether you're looking to dominate with AoE-focused clearing builds, leverage damage-over-time (DoT) effects, or execute critical burst setups, these loadouts have been thoroughly tested for effectiveness in both solo and team scenarios.
If you're just starting out, don't miss our Beginner’s Guide for Once Human for a thorough introduction to the game!

Final Tips for Optimizing Your Build
- Sync Weapon Effects and Mods: Select gear that amplifies your weapon’s elemental or status effects for maximum synergy.
- Keep Upgrading: The rarity and enhancement level of your gear significantly impact its performance. Always strive to update your equipment to stay ahead.
- Craft Backup Loadouts: Prepare a secondary build based on different elements to swiftly adapt to various mutant types or counter PvP strategies.
Each build in Once Human is tailored for specific scenarios, be it tackling boss fights, efficiently clearing waves, or executing quick PvP takedowns. Experiment with each loadout, fine-tune your gear mods, and switch builds based on the mission type or enemy resistance you face.
For the ultimate gaming experience—featuring lag-free aiming, the ability to farm using multiple instances, and swift inventory management—consider playing Once Human on BlueStacks. Enjoy full control support and ultra-smooth FPS to optimize your gameplay to the fullest.